Herpes viruses common in brains with Alzheimer’s disease

Two strains of the human herpes virus may contribute to Alzheimer's a new study shows

Two strains of the human herpes virus may contribute to Alzheimer's a new study shows

Doctors don't know what causes Alzheimer's or how to treat it best, but they have new evidence to suggest that a common virus may play a role in who gets it. NPR reports the study also found HHV-6 and HHV-7 may "put gas on the flame", as study author Joel Dudley puts it, meaning the viruses' presence could be speeding up the progress of the disease.

Scientists have found that Alzheimer's could be triggered by viruses that can affect the brain.

Researchers of a new study find evidence that backs the decades-old theory, opening the door for future researches. In their detailed analysis, researchers examined the postmortem brains of 622 people with Alzheimer's disease, and 322 brains of people without it, and found two herpes viruses that were abundant in the Alzheimer's brains.

There are multiple points of overlap between virus-host interactions and genes associated with Alzheimer's risk.

Someone in the United States develops Alzheimer's every 65 seconds, and by midcentury, it's expected to be every 33 seconds, according to the Alzheimer's Association. He explained that like many other scientific experiments.

This study has been enabled by the extensive molecular profiling of several large patient cohorts, generated in the course of the National Institute on Aging (NIA) Accelerating Medicines Partnership-Alzheimer's Disease (AMP-AD). The term "multi-omic" is used as shorthand to imply that data from genes, proteins, fats, and other tissue components are all assessed and then represented qualitatively and quantitatively in a complex mathematical model.

"This is the most compelling evidence ever presented that points to a viral contribution to the cause or progression of Alzheimer's", said study co-author Dr. Sam Gandy, a professor of neurology and psychiatry and director of the Center for Cognitive Health at Mount Sinai in NY. The research gives a ray of hope for the prevention of Alzheimer's with the use of antiviral drugs.

The scientists did not set out to look for a link between viruses and dementia.

"The new study is impressive and very well designed".

Millions of people across the globe are affected by the Alzheimer's disease but the main cause of the dementia is still unknown. "A similar situation arose recently in certain forms of Lou Gehrig's disease". Suzana Petanceska, PhD, who leads the AMP-AD project that supported the study, said in an NIH press release that the robust findings wouldn't have been possible without the program's open science data resources, especially the raw genomic data. "This research reinforces the complexity of Alzheimer's disease, creates opportunities to explore Alzheimer's more thoroughly, and highlights the importance of sharing data freely and widely with the research community".

The research concentrated on the brain of the people who died on account of Alzheimer's. Dudley is a member of the ASU-Banner Neurodegenerative Disease Research Center.

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